Whilst humans and other vertebrates appear outwardly symmetrical, internal features such as the heart, viscera and brain exhibit left-right asymmetries. Errors of leftright patterning present an important class of human birth defects, including congenital heart defects arising from dextrocardia. Considerable controversy exists about the nature and evolutionary conservation of the molecular mechanisms that allow embryos to reliably orient the leftright axis. Recent work has shown that mutations in the cytoskeletal protein tubulin that alter asymmetry in plants also affect very early steps of leftright patterning in nematode and frog embryos, as well as chirality of human cells in culture. Our data sheds new light, and asks new questions, about the role of the cytoskeleton in cell chirality an embryo laterality.